Published incidents and their proportions of human error

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Purpose - The information security field experiences a continuous stream of information security incidents and breaches, which are publicised by the media, public bodies and regulators. Despite the need for information security practices being recognised and in existence for some time the underlying general information security affecting tasks and causes of these incidents and breaches are not consistently understood, particularly with regard to human error. Methodology - This paper analyses recent published incidents and breaches to establish the proportions of human error, and where possible subsequently utilises the HEART human reliability analysis technique, which is established within the safety field. Findings - This analysis provides an understanding of the proportions of incidents and breaches that relate to human error as well as the common types of tasks that result in these incidents and breaches through adoption of methods applied within the safety field. Originality - This research provides original contribution to knowledge through the analysis of recent public sector information security incidents and breaches in order to understand the proportions that relate to human erro

Adhesive Through-Reinforcement Improves the Fracture Toughness of a Laminated Birch Wood Composite

In this paper we test the hypothesis that adhesive through-reinforcement in combination with glass-fibre reinforcement of adhesive bond lines will significantly improve the fracture toughness of a laminated birch wood composite. We test this hypothesis using a model composite consisting of perforated veneer that allowed a polyurethane adhesive to penetrate and reinforce veneers within the composite. Model composite specimens were tested for mode I fracture properties, and scanning electron microscopy was used to examine the microstructure of fracture surfaces. Our results clearly show that through-reinforcement, and also reinforcing adhesive bond lines with glass-fibre, significantly improved fracture toughness of the birch wood composite. Our results also indicate that improvements in fracture toughness depended on the level of reinforcement. Improvements in fracture toughness were related to the ability of the reinforcement to arrest crack development during fracture testing and the fibre bridging effect of glass-fibre in adhesive bond lines. We conclude that through-reinforcement is an effective way of improving the fracture toughness of laminated wood composites, but further research is needed to develop practical ways of creating such reinforcement in composites that more closely resemble commercial products

Classically integrable boundary conditions for symmetric-space sigma models

We investigate boundary conditions for the nonlinear sigma model on the compact symmetric space $G/H$, where $H \subset G$ is the subgroup fixed by an involution $\sigma$ of $G$. The Poisson brackets and the classical local conserved charges necessary for integrability are preserved by boundary conditions in correspondence with involutions which commute with $\sigma$. Applied to $SO(3)/SO(2)$, the nonlinear sigma model on $S^2$, these yield the great circles as boundary submanifolds. Applied to $G \times G/G$, they reproduce known results for the principal chiral model.Comment: 8 pages. v2 has an introduction added and a few minor correction

Three-Dimensional Multi-Relaxation Time (MRT) Lattice-Boltzmann Models for Multiphase Flow

In this paper, three-dimensional (3D) multi-relaxation time (MRT) lattice-Boltzmann (LB) models for multiphase flow are presented. In contrast to the Bhatnagar-Gross-Krook (BGK) model, a widely employed kinetic model, in MRT models the rates of relaxation processes owing to collisions of particle populations may be independently adjusted. As a result, the MRT models offer a significant improvement in numerical stability of the LB method for simulating fluids with lower viscosities. We show through the Chapman-Enskog multiscale analysis that the continuum limit behavior of 3D MRT LB models corresponds to that of the macroscopic dynamical equations for multiphase flow. We extend the 3D MRT LB models developed to represent multiphase flow with reduced compressibility effects. The multiphase models are evaluated by verifying the Laplace-Young relation for static drops and the frequency of oscillations of drops. The results show satisfactory agreement with available data and significant gains in numerical stability.Comment: Accepted for publication in the Journal of Computational Physic

Radio direction finding for maritime search and rescue

Melbourne, VI

Patterns of Tumor Necrosis Factor Inhibitor (TNFi) Biosimilar Use Across United States Rheumatology Practices.

ObjectiveIt is unclear if biosimilars of biologics for inflammatory arthritis are realizing their promise to increase competition and improve accessibility. This study evaluates biosimilar tumor necrosis factor inhibitor (TNFi) utilization across rheumatology practices in the United States and compares whether patients initiating biosimilars remain on these treatments at least as long as new initiators of bio-originators.MethodsWe identified a cohort of patients initiating a TNFi biosimilar between January 2017 and September 2018 from an electronic health record registry containing data from 218 rheumatology practices and over 1 million rheumatology patients in the United States. We also identified a cohort of patients who initiated the bio-originator TNFi during the same period. We calculated the proportion of biosimilar prescriptions compared with other TNFi's and compared persistence on these therapies, adjusting for age, sex, diagnoses codes, and insurance type.ResultsWe identified 909 patients prescribed the biosimilar infliximab-dyyb, the only biosimilar prescribed, and 4413 patients with a new prescription for the bio-originator infliximab. Biosimilar patients tended to be older, have a diagnosis code for rheumatoid arthritis, and covered by Medicare insurance. Over the study period, biosimilar prescriptions reached a maximum of 3.5% of all TNFi prescriptions. Patients persisted on the biosimilar at least as long as the bio-originator infliximab (hazard ratio [HR] 0.83, P = 0.07).ConclusionThe uptake of biosimilars in the United States remains low despite persistence on infliximab-dyyb being similar to the infliximab bio-originator. These results add to clinical studies that should provide greater confidence to patients and physicians regarding biosimilar use

Using Curcumin Nano-Lipid Particles in a Therapeutic Approach

Curcumin (Curcuma longa) is a plant-based polyphenol known to have several medicinal properties. Although several promising effects of using curcumin in clinical trials have been observed, its overall medicinal qualities are still limited due to low bioavailability. In order to increase the bioavailability, we are embedding curcumin within Nano-Lipid Particles (both curcumin telodendrimer discs and curcumin tNLPs). Telodendrimer nanolipoprotein particles (tNLPs) are discoidal self-assemblies containing lipids and apolipoproteins which can be used as a vehicle to carry proteins and other small molecules to the cell. Telodendrimer NLPs have been used to increase the bioavailability of drugs, and provide an ideal platform to increase curcumin bioavailability. The generation of tNLPs can be accomplished using several methods; such as cellfree assembly and in-vitro assembly. Curcumin telodendrimer discs (curcumin telo-discs) are a nano-lipid mixture of lipids, curcumin, and telodendrimer that acts as the basis for the curcumin tNLP reaction. Using the curcumin telo-disc as the starting additive, we demonstrate that we can purify properly formed curcumin tNLPs via affinity columns and size-exclusion chromatography (SEC). Here, we show that with two separate methods: a cell-free expressed method and in-vitro assembly, we can demonstrate that curcumin

A Stretch/Bend Method for In Situ Measurement of the Delamination Toughness of Coatings and Films Attached to Substrates

A stretch/bend method for the in situ measurement of the delamination toughness of coatings attached to substrates is described. A beam theory analysis is presented that illustrates the main features of the test. The analysis is general and allows for the presence of residual stress. It reveals that the test produces stable extension of delaminations, rendering it suitable for multiple measurements in a single test. It also provides scaling relations and enables estimates of the loads needed to extend delaminations. Finite element calculations reveal that the beam theory solutions are accurate for slender beams, but overestimate the energy release rate for stubbier configurations and short delaminations. The substantial influence of residual stress on the energy release rate and phase angle is highly dependent on parameters such as the thickness and modulus ratio for the two layers. Its effect must be included to obtain viable measurements of toughness. In a companion paper, the method has been applied to a columnar thermal barrier coating deposited onto a Ni-based super-alloy.Engineering and Applied Science